淫羊藿对骨髓间充质干细胞影响的研究进展

李烨,肖亚平,李晶晶,徐晓玉

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (24) : 2137-2140.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (24) : 2137-2140. DOI: 10.11669/cpj.2017.24.001
综述

淫羊藿对骨髓间充质干细胞影响的研究进展

  • 李烨1,2,肖亚平1,李晶晶1,徐晓玉1*
作者信息 +

Research Progress of Role of Epimedium in Promoting Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Treating Osteoporosis

  • LI Ye1,2, XIAO Ya-ping1, LI Jing-jing1, XU Xiao-yu1*
Author information +
文章历史 +

摘要

促进骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)成骨并抑制其成脂分化是目前骨质疏松症治疗的新靶点。淫羊藿防治骨质疏松症的机制已成为近年来研究热点,研究发现其具有促进BMSCs成骨并抑制其成脂分化等作用。笔者以补肾代表中药淫羊藿促进BMSCs成骨并抑制其成脂分化进展作一综述,为骨质疏松症的干细胞治疗提供新的思路。

Abstract

Promoting osteogenesis and suppressing adipogenesis of bone marrow mesenchymal stem cells (BMSCs) have been a new target for treatment of osteoporosis. The therapeutic effects and mechanisms of Epimedium in treating osteoporosis have become the focus under study. Experimental studies have shown that epimedium has effects of promoting osteogenesis and suppressing adipogenesis of BMSCs. This paper reviews the role of Epimedium, a representative traditional Chinese kidney-tonifying drug, in promoting osteogenesis and suppressing adipogenesis of BMSCs, so as to provide new ideas for stem cell treatment of osteoporosis.

关键词

骨质疏松 / 淫羊藿 / 骨髓间充质干细胞 / 成骨分化 / 成脂分化

Key words

osteoporosis / Epimedium / bone marrow mesenchymal stem cell / osteogenesis / adipogenesis

引用本文

导出引用
李烨,肖亚平,李晶晶,徐晓玉. 淫羊藿对骨髓间充质干细胞影响的研究进展[J]. 中国药学杂志, 2017, 52(24): 2137-2140 https://doi.org/10.11669/cpj.2017.24.001
LI Ye, XIAO Ya-ping, LI Jing-jing, XU Xiao-yu. Research Progress of Role of Epimedium in Promoting Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Treating Osteoporosis
[J]. Chinese Pharmaceutical Journal, 2017, 52(24): 2137-2140 https://doi.org/10.11669/cpj.2017.24.001
中图分类号: R282   

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基金

国家自然科学基金面上项目资助(81473549);中国博士后科学基金资助项目(2014M562272);重庆市卫生局中医药科研项目资助(zy201602125);中央高校基本科研业务费专项资助(XDJK2017D158)
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